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Development of a dissolving microneedle patch for transdermal delivery of SARS-CoV-2 mRNA vaccine with enhanced stability and immunogenicity

Zequn Tang, Tong Su, Ting Jiang, Jiayi Hu, Daiyan Chen, Xi Li, Jing Lü, Jinzhong Lin, Teng Shen

2025Journal of Controlled Release11 citationsDOI

Topics & Concepts

ImmunogenicityTransdermalChemistryPolyvinylpyrrolidoneIn vivoPharmacologyMessenger RNAPolyvinyl alcoholEx vivoNanocapsulesDissolutionNasal administrationNanoparticleToxicityBiomedical engineeringIn vitroConjugateSystemic administrationAntigenDrug deliveryMicroparticleDosage formDrug carrierAdvancements in Transdermal Drug DeliveryLipid Membrane Structure and BehaviorToxin Mechanisms and Immunotoxins
Development of a dissolving microneedle patch for transdermal delivery of SARS-CoV-2 mRNA vaccine with enhanced stability and immunogenicity | Litcius