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Benzothiazole-based 1,3,4-thiadiazole hybrids derivatives as effective inhibitors of urease and thymidine phosphorylase: Synthesis, in vitro and in silico approaches

Yousaf Khan, Wajid Rehman, Rafaqat Hussain, Shoaib Khan, Aneela Maalik

2023Journal of Molecular Structure27 citationsDOI

Topics & Concepts

ChemistryBenzothiazoleThymidine phosphorylaseEnzymeIC50ThioureaUreaseGlycogen phosphorylaseDocking (animal)In vitroThymidineStereochemistryIn silicoCombinatorial chemistryBiochemistryOrganic chemistryGeneMedicineNursingBiochemical and Molecular ResearchSynthesis and biological activityCancer therapeutics and mechanisms
Benzothiazole-based 1,3,4-thiadiazole hybrids derivatives as effective inhibitors of urease and thymidine phosphorylase: Synthesis, in vitro and in silico approaches | Litcius