<i>Ganoderma lucidum</i>: a comprehensive review of phytochemistry, efficacy, safety and clinical study
Sijia Wu, Siyuan Zhang, Bo Peng, Dechao Tan, Mingyue Wu, Jinchao Wei, Yitao Wang, Hua Luo
Abstract
<i>Ganoderma lucidum</i> (<i>G. lucidum</i>), one of the most well-known edible fungi, is believed to be very beneficial for longevity and vitality. A long usage history suggests that <i>G. lucidum</i> has various clinical therapeutic effects. And experimental studies have confirmed that <i>G. lucidum</i> has multiple pharmacological effects, including antitumor, anti-microbial, anti-HIV protease, and antidiabetic activity and so on. With the deepening of research, more than 300 compounds have been isolated from <i>G. lucidum</i>. There is an increasing population of G. lucidum-based products, and its international development is expanding. Currently, <i>G. lucidum</i> has drawn much attention to its chemical composition, therapeutic effect, clinical value, and safety. This paper provides a comprehensive review of these aspects to enhance the global promotion of <i>G. lucidum</i>.