CircRNA_400029 promotes the aggressive behaviors of cervical cancer by regulation of miR-1285-3p/TLN1 axis
Yue Ma, Jing Liu, Zhuo Yang, Peng Chen, Danbo Wang
Abstract
Background: Cervical cancer (CC) is the highest incidence of female malignant tumor in China. Circular RNAs (circRNAs) has been reported to affect CC progression by altering mRNA stability at the transcriptional level or binding to miRNAs to produce competitive endogenous RNA (ceRNA). For this purpose, our study was aimed to investigate the function effects and the potential regulatory mechanism of the circRNA_400029 in CC cells.
Topics & Concepts
Competing endogenous RNAGene knockdownApoptosisCell growthmicroRNAFlow cytometryCell cycleCancer researchDownregulation and upregulationChemistryCellMolecular biologyWestern blotCell migrationReporter geneBiologyGene expressionGeneLong non-coding RNABiochemistryCircular RNAs in diseases