Pharmacologically inherited carbon dots from <i>Salvia miltiorrhiza</i> with potent antioxidant activity and multi-pathway modulation for myocardial ischemia-reperfusion injury therapy
Kai Zhang, Zhenyuan Wang, L Zhang, Hao Wu, Liu Jing, Mingzhen Zhang, Zhichao Deng, Ruina Liu
Abstract
This study introduces SM-CDs as biocompatible nanozymes with potent antioxidant and cardioprotective potential for myocardial I/R injury.
Topics & Concepts
PharmacologyReactive oxygen speciesChemistryAntioxidantSuperoxide dismutaseSignal transductionOxidative stressIntracellularFibrosisMyocardial fibrosisCardiac fibrosisMacrophagePathogenesisTherapeutic effectMedicineSuperoxideTranscriptomeCardioprotectionCardiac dysfunctionReperfusion injuryBiochemistryOxidative phosphorylationPI3K/AKT/mTOR pathwayReceptorAdvanced Nanomaterials in CatalysisCarbon and Quantum Dots ApplicationsElectrochemical sensors and biosensors