A photoswitchable GPCR-based opsin for presynaptic inhibition
Bryan A. Copits, Raaj Gowrishankar, Patrick O’Neill, Jun-Nan Li, Kasey S. Girven, Judy J. Yoo, Xenia Meshik, Kyle E. Parker, Skylar M. Spangler, Abigail J. Elerding, Bobbie J. Brown, Sofia E. Shirley, Kelly K.L., Alexis M. Vasquez, M. Ständer, Vani Kalyanaraman, Sherri K. Vogt, Vijay K. Samineni, Tommaso Patriarchi, Lin Tian, N. Gautam, Roger K. Sunahara, Robert W. Gereau, Michael R. Bruchas
Topics & Concepts
OptogeneticsOpsinNeurotransmissionNeuroscienceInhibitory postsynaptic potentialChannelrhodopsinPresynaptic inhibitionDopamineRhodopsinChemistryGlutamate receptorG protein-coupled receptorExcitatory postsynaptic potentialBiological neural networkNeurotransmitterBiophysicsBiologyCell biologySignal transductionReceptorBiochemistryCentral nervous systemRetinalPhotoreceptor and optogenetics researchRetinal Development and DisordersPhotochromic and Fluorescence Chemistry