Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human <i>FCGRT</i> transgenic mice
Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin, Michael V. Wiles
Abstract
chimeric antibodies at physiologically relevant levels, which can be further heightened by immunization. This endogenous chimeric IgG1 significantly dampens the serum half-life of administered humanized mAbs in an hFCGRT-dependent manner. Thus, such IgG1-Fc humanized mice may provide a more physiologically relevant competitive hFCGRT-humanized mouse model for the preclinical development of human IgG-based biologics.
Topics & Concepts
Humanized mouseNeonatal Fc receptorAntibodyMonoclonal antibodyImmunoglobulin GTransgeneImmunologyGenetically modified mouseBiologyVirologyImmune systemGeneGeneticsMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyImmune Cell Function and Interaction