Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing
Friederike Knipping, Gregory A. Newby, Cindy Eide, Amber McElroy, Sarah C. Nielsen, Kyle D. Smith, Yongxing Fang, Tatjana I. Cornu, Caroline Costa, Alejandra Gutiérrez-Guerrero, Samuel P. Bingea, Colby J. Feser, Benjamin J. Steinbeck, Keli L. Hippen, Bruce R. Blazar, Anton P. McCaffrey, Claudio Mussolino, Els Verhoeyen, Jakub Tolar, David R. Liu, Mark J. Osborn
Topics & Concepts
BiologyGenome editingChemokine receptor CCR5HaematopoiesisCXCR4Progenitor cellStem cellPoint mutationCD34GeneticsTransduction (biophysics)VirologyCell biologyGeneReceptorMutationGenomeChemokine receptorBiochemistryChemokineCRISPR and Genetic EngineeringHIV Research and TreatmentAdvanced biosensing and bioanalysis techniques