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Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing

Friederike Knipping, Gregory A. Newby, Cindy Eide, Amber McElroy, Sarah C. Nielsen, Kyle D. Smith, Yongxing Fang, Tatjana I. Cornu, Caroline Costa, Alejandra Gutiérrez-Guerrero, Samuel P. Bingea, Colby J. Feser, Benjamin J. Steinbeck, Keli L. Hippen, Bruce R. Blazar, Anton P. McCaffrey, Claudio Mussolino, Els Verhoeyen, Jakub Tolar, David R. Liu, Mark J. Osborn

2021Molecular Therapy46 citationsDOIOpen Access PDF

Topics & Concepts

BiologyGenome editingChemokine receptor CCR5HaematopoiesisCXCR4Progenitor cellStem cellPoint mutationCD34GeneticsTransduction (biophysics)VirologyCell biologyGeneReceptorMutationGenomeChemokine receptorBiochemistryChemokineCRISPR and Genetic EngineeringHIV Research and TreatmentAdvanced biosensing and bioanalysis techniques
Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing | Litcius