Carboxy-terminal dendrimers with phenylalanine for a pH-sensitive delivery system into immune cells including T cells
Hiroya Shiba, Misaki Nishio, Mei Sawada, Mamiko Tamaki, Masataka Michigami, Shinya Nakai, Ikuhiko Nakase, Ikuo Fujii, Akikazu Matsumoto, Chie Kojima
Abstract
endocytosis, and their cellular uptake was enhanced under weak acidic conditions (pH 6.5). Our results showed that Phe- and CHex-modified dendrimers have a delivery potential to T cells and their subsets, which may be useful for cancer immunotherapy.
Topics & Concepts
DendrimerPhenylalanineImmune systemTerminal (telecommunication)Delivery systemBiochemistryBiophysicsChemistryMaterials scienceNanotechnologyAmino acidImmunologyBiologyPharmacologyComputer scienceTelecommunicationsDendrimers and Hyperbranched PolymersRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery