Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals
Christoffer Martinussen, Maria S. Svane, Kirstine N. Bojsen‐Møller, Christian Zinck Jensen, Viggo B. Kristiansen, Angie L. Bookout, Sebastian B. Jørgensen, Jens J. Holst, Nicolai J. Wewer Albrechtsen, Sten Madsbad, Rune E. Kuhre
Abstract
Our combined data show that GDF15 does not increase in response to a liquid meal. Moreover, we show for the first time that ingestion of sucrose, isomaltose, glucose, fat, or protein also does not increase plasma GDF15 concentrations, questioning the role of GDF15 in regulation of food source preference. Finally, we find that neither fasting nor postprandial plasma GDF15 concentrations are increased in individuals with previous bariatric surgery compared with unoperated body mass index (BMI)-matched controls.
Topics & Concepts
PostprandialInternal medicineMedicineMealSleeve gastrectomyEndocrinologyIngestionGastric bypassCohortWeight lossObesityInsulinGDF15 and Related BiomarkersNutrition and Health in AgingMacrophage Migration Inhibitory Factor