Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis
Anna Evans Phillips, Annette Wilson, Phil J. Greer, Alice Hinton, Stacey Culp, Pedram Paragomi, Ioannis Pothoulakis, Vijay Singh, Peter J. Lee, Ila Lahooti, David C. Whitcomb, Georgios I. Papachristou
2023American Journal of Physiology-Gastrointestinal and Liver Physiology20 citationsDOIOpen Access PDF
Abstract
Drivers of the inflammatory response in acute pancreatitis remain incompletely understood. Unsaturated fatty acids, specifically palmitoleic, appear to have an association with more severe acute pancreatitis. This finding presents a new clinical understanding of fatty acid toxicity and highlights a potential future target for treatment in severe acute pancreatitis.
Topics & Concepts
LipotoxicityAcute pancreatitisInternal medicineEndocrinologyPancreatitisMedicineLipaseChemistryBiochemistryInsulinEnzymeInsulin resistancePancreatitis Pathology and TreatmentLiver Disease Diagnosis and TreatmentDiabetes and associated disorders