Interleukin-7 protects CD8 <sup>+</sup> T cells from adenosine-mediated immunosuppression
Altay Koyaş, Suat Tüçer, Merve Kayhan, Ali Can Savas, Imran Akdemir, Caglar Cekic
Abstract
T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.
Topics & Concepts
AdenosineCytokineImmunosuppressionCancer researchCD8Adenosine receptorCytotoxic T cellBiologySignal transductionCell biologyImmune systemImmunologyReceptorChemistryEndocrinologyBiochemistryAgonistIn vitroCAR-T cell therapy researchImmune Cell Function and InteractionAdenosine and Purinergic Signaling