The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair
Xiaoxue Li, Aiting Liu, Chen Xie, Yanlian Chen, Kuan Zeng, Changming Xie, Zhengzhipeng Zhang, Pei Luo, Hui Huang
Topics & Concepts
GATA6Vascular smooth muscleBiologySenescenceDownregulation and upregulationCalcificationPremature agingCancer researchTranscription factorEndocrinologyInternal medicineCell biologyMedicineBiochemistryGeneticsSmooth muscleGeneTelomeres, Telomerase, and SenescenceRNA modifications and cancerMicroRNA in disease regulation