Catalytic Homologation‐Allylboration Sequence for Diastereo‐ and Enantioselective Synthesis of Densely Functionalized β‐Fluorohydrins with Tertiary Fluoride Stereocenters
Qiang Wang, Lars Eriksson, Kálmán J. Szabó
Abstract
Homologation of trisubstituted fluoroalkenes followed by allylboration of aldehyde, ketone and imine substrates is suitable for synthesis of β-fluorohydrin and amine products. In the presence of (R)-iodo-BINOL catalyst enantioselectivities up to 99 % can be achieved by formation of a single stereoisomer with adjacent stereocenters, of which one is a tertiary C-F center.
Topics & Concepts
StereocenterEnantioselective synthesisAldehydeImineCatalysisTertiary amineChemistryOrganic chemistryKetoneAmine gas treatingFluorideInorganic chemistryFluorine in Organic ChemistryAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis