KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8<sup>+</sup> T-cell-dependent antitumor immunity
Qi Wu, Zhou Liu, Zhijie Gao, Yao Luo, Fubing Li, Chuanyu Yang, Tiantian Wang, Xiangyu Meng, Haijun Chen, Juanjuan Li, Yanjie Kong, Chao Dong, Si Sun, Ceshi Chen
Abstract
Our results identified a novel mechanism responsible for KLF5-mediated immunosuppression in TME, and targeting the KLF5/COX2/PGE2 axis is a critical immunotherapy sensitizer.
Topics & Concepts
Cancer researchBiologyImmune systemTumor microenvironmentCD8T cellImmune checkpointChromatin immunoprecipitationTranscriptomeImmunotherapyCellCancer immunotherapyFlow cytometryGene expressionMolecular biologyImmunologyGenePromoterGeneticsBiochemistryKruppel-like factors researchEpigenetics and DNA MethylationCancer-related gene regulation