Copper-catalyzed C–H/N–H annulation of enaminones and alkynyl esters for densely substituted pyrrole synthesis
Leiqing Fu, Jie‐Ping Wan, Liyun Zhou, Yunyun Liu
Abstract
The synthesis of 2-vinyl pyrroles has been achieved via copper-catalyzed cascade reactions of enaminones and alkyl propiolates. The synthesis of 2,3-dicarboxylate-functionalized products has been tuned by using internal alkynyl dicarboxylates.
Topics & Concepts
AnnulationPyrroleCatalysisChemistryCopperCombinatorial chemistryRing (chemistry)Medicinal chemistryOrganic chemistryPolymer chemistrySynthesis and Characterization of PyrrolesCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry