TET1 downregulates epithelial-mesenchymal transition and chemoresistance in PDAC by demethylating CHL1 to inhibit the Hedgehog signaling pathway
Hao Li, Wang Jiang, Xue-Ni Liu, Liyun Yuan, Tianjiao Li, Shuo Li, Shuaishuai Xu, Wuhu Zhang, He-Li Gao, Xuan Han, Wenquan Wang, Chuntao Wu, Xianjun Yu, Huaxiang Xu, Liang Liu
Topics & Concepts
Cancer researchBiologyHedgehog signaling pathwayDemethylating agentGene knockdownGene silencingGLI1Epithelial–mesenchymal transitionDNA methylationDownregulation and upregulationSignal transductionCell biologyCell cultureGene expressionGeneticsGenePancreatic and Hepatic Oncology ResearchEpigenetics and DNA MethylationHedgehog Signaling Pathway Studies