C(sp<sup>3</sup>)–H Aerobic Alkenylation of Tetrahydroisoquinolines via Organic Electrosynthesis
Zeng He, Huilin Liu, Zhenhua Wang, Ke-Jing Jiao, Zimeng Li, Zhang-Jian Li, Ping Fang, Tian‐Sheng Mei
Abstract
-aryl-tetrahydroisoquinoline (THIQ) has been developed by the combination of electrooxidation and a copper catalyst. The corresponding products were obtained with good to excellent yields under mild conditions. Besides, the addition of TEMPO as an electron mediator is crucial to this transformation, since the oxidative reaction could proceed under a low electrode potential. In addition, the catalytic asymmetric variant has also been demonstrated with good enantioselectivity.
Topics & Concepts
ElectrosynthesisChemistryOrganic chemistryElectrochemistryPhysical chemistryElectrodeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques