Cu-Catalyzed Site-Selective and Enantioselective Ring Opening of Cyclic Diaryliodoniums with 1,2,3-Triazoles
Zengyin Chao, Mingming Ma, Zhenhua Gu
Abstract
A Cu-catalyzed enantioselective ring-opening/triazolylation reaction is reported. The reaction shows excellent chemoselectivity regarding the three different nitrogen atoms of 1,2,3-triazoles. The optically enriched axially chiral aryl iodides thus obtained were readily derivatized to different types of chiral phosphine ligands and their corresponding copper or palladium complexes.
Topics & Concepts
Enantioselective synthesisChemistryChemoselectivityPhosphineRing (chemistry)CatalysisArylPalladiumCombinatorial chemistryCopperOptically activeStereochemistryMedicinal chemistryOrganic chemistryAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAlkaloids: synthesis and pharmacology