Solid-State Nanopore Platform Integrated with Machine Learning for Digital Diagnosis of Virus Infection
Akihide Arima, Makusu Tsutsui, Takashi Washio, Yoshinobu Baba, Tomoji Kawai
Abstract
The history of viruses in human society can never be taught without the history of detection and treatment. As an ancient example, Egyptian mummies have been found to have scars from smallpox infection.1 There have been various viral pandemics; however, the first virus to be discovered was tobacco mosaic virus (TMV) in 1892.2 Russian microbiologist D. I. Ivanovsky found an infectious agent in the extraction liquid of tobacco plants passed through a Chamberland filter, which filtered out bacteria. The technology of the day could not detect this mysterious factor, and observation had to await the development of scanning electron microscopy (SEM). To date, various techniques have revealed the structure and properties of numerous virus species.