Comparative study of aryl halides in Pd-mediated reactions: key factors beyond the oxidative addition step
Alexey S. Galushko, Darya O. Prima, Julia V. Burykina, Valentine P. Ananikov
Abstract
The comparative experimental study of Ar–X (X = Cl, Br, I) reactivity and analysis reported herein suggest that oxidative addition cannot be considered the sole reason of the observed low reactivity of aryl chlorides.
Topics & Concepts
Reactivity (psychology)ArylOxidative additionOxidative phosphorylationChemistryHalideAryl halideMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisBiochemistryAlkylMedicineAlternative medicinePathologyCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions