Transmembrane anion transport mediated by sigma-hole interactions
Andrew Docker, Matthew J. Langton
Abstract
Supramolecular transmembrane anion transporters are promising therapeutics for channelopathies and typically operate via hydrogen bonding. Sigma-hole interactions including halogen bonding (XB), chalcogen bonding (ChB), and pnictogen bonding (PnB) have emerged as promising alternatives in both transport activity and selectivity. This forum highlights recent advances and identifies anion transport properties unique to sigma-hole interactions.
Topics & Concepts
Hydrogen bondHalogen bondSupramolecular chemistryTransmembrane proteinPnictogenIonChemistryTransporterSigmaIon transporterNanotechnologyMaterials scienceCrystallographyBiochemistryMoleculePhysicsOrganic chemistryCrystal structureCondensed matter physicsReceptorQuantum mechanicsSuperconductivityGeneMolecular Sensors and Ion DetectionCrystallography and molecular interactionsCoordination Chemistry and Organometallics