Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
Xingwang Wu, Wanran Li, Yun Zheng
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.
Topics & Concepts
microRNAAutism spectrum disorderAutismPathogenesisBiologyBioinformaticsNeurodevelopmental disorderNon-coding RNAComputational biologyGeneticsMedicineNeuroscienceGenePsychiatryImmunologyMicroRNA in disease regulationGenetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research