DCLK1 autoinhibition and activation in tumorigenesis
Linna Cheng, Zejing Yang, Wenhao Guo, Chengyong Wu, Shufang Liang, Aiping Tong, Zhongwei Cao, Rick F. Thorne, Shengyong Yang, Yamei Yu, Qiang Chen
Abstract
-dependent manner, which releases the autoinhibition. We also analyzed cancer-associated mutations occurring in the AID and elucidate how these mutations disrupt DCLK1 autoinhibition to elicit kinase activity upregulation. Our results present a molecular mechanism for autoinhibition and activation of DCLK1 kinase activity and provide insights into DCLK1-associated tumorigenesis.
Topics & Concepts
CarcinogenesisKinaseDownregulation and upregulationProtein kinase domainCell biologyBiologyActivator (genetics)ChemistryBiochemistryMutantGeneCancer, Hypoxia, and MetabolismHippo pathway signaling and YAP/TAZNeuroblastoma Research and Treatments