Synthesis and evaluation of the antiproliferative activity of new heterylmethylidene derivatives of imidazothiazolotriazinones
Alexei N. Izmest’ev, Галина А. Газиева, Л. В. Аникина, S. A. Pukhov, Валентина А. Карноухова, Natalya G. Kolotyrkina, Ангелина Н. Кравченко
Abstract
Two series of regioisomeric heterylmethylidene derivatives of imidazo[4,5-<italic>e</italic>]thiazolo[3,2-<italic>b</italic>]-1,2,4-triazines and imidazo[4,5-<italic>e</italic>]thiazolo[2,3-<italic>c</italic>]-1,2,4-triazines were synthesized. Several compounds exhibiting high antiproliferative activity were found.
Topics & Concepts
ChemistryStereochemistrySynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis of heterocyclic compounds