The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study
María B. Arriaga, Mariana Araújo‐Pereira, Beatriz Barreto‐Duarte, Betânia M. F. Nogueira, Maria Vitória C.N.S. Freire, Artur T. L. Queiroz, Moreno Magalhães de Souza Rodrigues, Michael S. Rocha, Alexandra B. Souza, Renata Spener-Gomes, Anna Cristina Calçada Carvalho, Marina C. Figueiredo, Megan Turner, Betina Durovni, José Roberto Lapa e Silva, Afrânio Lineu Kritski, Solange Cavalcante, Valéria C. Rolla, Marcelo Cordeiro‐Santos, Timothy R. Sterling, Bruno B. Andrade, Alice M S Andrade, Vanessa Nascimento, Hayna Malta‐Santos, Jéssica Rebouças-Silva, Allyson Guimarães Costa, Jaquelane Silva, Jamile G. de Oliveira, Aline Benjamin, Adriano Gomes-Silva, Flávia Marinho Sant’Anna, Francine P Ignácio, Maria Cristina S. Lourenço, Elisângela Silva, Adriana S. R. Moreira, Mayla Mello
Abstract
BACKGROUND: It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB). METHODS: Culture-confirmed, drug-susceptible PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort between 2015 and 2019 (N = 643) were stratified based on glycemic status according to baseline glycated hemoglobin. Unfavorable tuberculosis (TB) outcome was defined as treatment failure or modification, recurrence, or death; favorable outcome was cure or treatment completion. We corroborated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015-2019 (N = 20 989). Logistic regression models evaluated associations between glycemic status and outcomes. RESULTS: In both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with smoking, illicit drug use, and human immunodeficiency virus infection. Diabetes, but not prediabetes, was associated with unfavorable outcomes in the RePORT-Brazil (adjusted relative risk [aRR], 2.45; P < .001) and SINAN (aRR, 1.76; P < .001) cohorts. Furthermore, diabetes was associated with high risk of death (during TB treatment) in both RePORT-Brazil (aRR, 2.16; P = .040) and SINAN (aRR, 1.93; P = .001). CONCLUSIONS: Diabetes was associated with an increased risk of unfavorable outcomes and mortality in Brazilian PWTB. Interventions to improve TB treatment outcomes in persons with diabetes are needed.