Programmable Bispecific Nano-immunoengager That Captures T Cells and Reprograms Tumor Microenvironment
Lu Zhang, Ruonan Bo, Yi Wu, Longmeng Li, Zheng Zhu, Ai‐Hong Ma, Wenwu Xiao, Yanyu Huang, Tatu Rojalin, Xingbin Yin, Chunping Mao, Fengyi Wang, Yongheng Wang, Hongyong Zhang, Kelmen E. Low, Kiana Lee, Yousif Ajena, Di Jing, Dalin Zhang, Christopher M. Baehr, Ruiwu Liu, Lei Wang, Yuanpei Li, Kit S. Lam
Abstract
structural transformation-based supramolecular bispecific NIE represents an innovative class of programmable receptor-mediated targeted immunotherapeutics to greatly enhance ICB therapy against cancers.
Topics & Concepts
Tumor microenvironmentCancer researchImmune checkpointImmune systemImmunotherapyIn vivoChemistryMedicineBiologyTumor cellsImmunologyBiotechnologyImmunotherapy and Immune ResponsesNanoplatforms for cancer theranosticsPeptidase Inhibition and Analysis