Pentoxifylline for intermittent claudication
Cathryn Broderick, Rachel Forster, Mohammed Abdel-Hadi, Kareem Salhiyyah
Abstract
Intermittent claudication (IC) is a symptom of peripheral arterial disease (PAD) and is associated with high morbidity and mortality. Pentoxifylline, one of many drugs used to treat IC, acts by decreasing blood viscosity, improving erythrocyte flexibility, and promoting microcirculatory flow and tissue oxygen concentration. Many studies have evaluated the efficacy of pentoxifylline in treating people with PAD, but results of these studies are variable. This is the second update of a review first published in 2012.
Topics & Concepts
PentoxifyllineMedicineIntermittent claudicationClaudicationPlaceboPhysical therapyRandomized controlled trialCochrane LibraryClinical trialCINAHLInternal medicinePsychological interventionArterial diseaseVascular diseaseAlternative medicinePathologyPsychiatryPeripheral Artery Disease ManagementDiagnosis and Treatment of Venous DiseasesVascular Procedures and Complications