Guanidinium–amino acid hydrogen-bonding interactions in protein crystal structures: implications for guanidinium-induced protein denaturation
Indu Negi, Raman Jangra, Amit Gharu, John F. Trant, Purshotam Sharma
Abstract
Structural analysis of guanidinium–amino acid interaction pairs in protein crystal structures is coupled with an effective scheme for classifying the optimized pairs, to gain understanding of the guanidinium:protein hydrogen bonding modes.
Topics & Concepts
Hydrogen bondChemistryAmino acidNon-covalent interactionsCrystallographyDenaturation (fissile materials)Hydrophobic effectStereochemistryMoleculeBiochemistryOrganic chemistryNuclear chemistryProtein Structure and DynamicsEnzyme Structure and FunctionCrystallography and molecular interactions