Treatment of Relapsing HPV Diseases by Restored Function of Natural Killer Cells
Andrea Lisco, Amy P. Hsu, Dimana Dimitrova, Diana M. Proctor, Emily M. Mace, Peiying Ye, Megan Anderson, Stephanie N. Hicks, Christopher Grivas, Dima A. Hammoud, Maura Manion, Gabriel J. Starrett, Alvin Farrel, Kerry Dobbs, Isaac Brownell, Christopher B. Buck, Luigi D. Notarangelo, Jordan S. Orange, Warren J. Leonard, Michael I. Orestes, Anju T. Peters, Jennifer A. Kanakry, Julia A. Segre, Heidi H. Kong, Irini Sereti
Abstract
), which was somatically reverted in T cells but not in natural killer (NK) cells. Allogeneic hematopoietic-cell transplantation led to restoration of NK cytotoxicity, with normalization of the skin microbiome and persistent remission of all HPV-related diseases. NK cytotoxicity appears to play a role in containing HPV colonization and the ensuing HPV-related hyperplastic or dysplastic lesions. (Funded by the National Institutes of Health and the Herbert Irving Comprehensive Cancer Center Flow Cytometry Shared Resources.).