Phloretin ameliorates diabetic nephropathy by inhibiting nephrin and podocin reduction through a non-hypoglycemic effect
Jia Liu, Mingcheng Sun, Yong Xia, Xiaopei Cui, Jingjing Jiang
Abstract
Phloretin has a protective effect on diabetic nephropathy. This beneficial effect possibly involves a non-hypoglycemic mechanism that preserves nephrin and podocin levels, thereby protecting podocytes and GFB from diabetic injury.
Topics & Concepts
PhloretinPodocinNephrinPodocyteSlit diaphragmChemistryEndocrinologyGlomerular basement membraneInternal medicinePharmacologyDiabetic nephropathyTBARSDiabetes mellitusOxidative stressKidneyMedicineBiochemistryLipid peroxidationGlomerulonephritisProteinuriaRenal Diseases and GlomerulopathiesChronic Kidney Disease and Diabetes