Analysis of Tryptophan Metabolites in Serum Using Wide-Isolation Strategies for UHPLC–HRMS/MS
Vanessa Rubio, Joy Cagmat, Gary P. Wang, Richard A. Yost, Timothy J. Garrett
Abstract
gut microbiota states was used to quantitate pathway-specific metabolites as well as obtain full profiling information. The quantitative and qualitative results revealed the preservation of the primary pathways of degradation in the kynurenine pathway to potentially produce primary products such as nicotinamide during stress-induced dietary states.
Topics & Concepts
ChemistryAnalyteMetabolomicsMass spectrometryChromatographyFragmentation (computing)Qualitative analysisComputational biologyBiological systemComputer scienceOperating systemQualitative researchBiologySociologySocial scienceMetabolomics and Mass Spectrometry StudiesTryptophan and brain disordersGut microbiota and health