Catalyst-free, scalable heterocyclic flow photocyclopropanation
Viktor Klöpfer, Robert Eckl, Johannes Floß, Philippe M. C. Roth, Oliver Reiser, Joshua P. Barham
Abstract
Visible light continuous flow photocyclopropanation of heterocyclic compounds is reported in a non-chlorinated biodegradable solvent. Design of Experiments optimization was used to arrive at optimal conditions that are safe, sustainable and scalable.
Topics & Concepts
ScalabilityFlow chemistryCatalysisContinuous flowFlow (mathematics)ChemistryProcess engineeringCombinatorial chemistryBiochemical engineeringComputer scienceSolventOrganic chemistryChemical engineeringNanotechnologyMaterials scienceEngineeringMathematicsDatabaseGeometryCyclopropane Reaction Mechanisms