Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the Long Terminal Repeat
Gregory A. Viglianti, Vicente Planelles, Timothy M. Hanley
Abstract
The major barrier toward the eradication of HIV-1 infection is the presence of a small reservoir of latently infected cells, which include CD4 + T cells and macrophages that escape immune-mediated clearance and the effects of antiretroviral therapy. There remain crucial gaps in our understanding of the molecular mechanisms that lead to transcriptionally silent or latent HIV-1 infection of macrophages.
Topics & Concepts
BiologyInterferon regulatory factorsTRIFInterferonPsychological repressionTLR4TLR2Viral replicationMicrobiologySignal transducing adaptor proteinVirologyCell biologySignal transductionToll-like receptorInnate immune systemImmunologyImmune systemVirusGeneGeneticsGene expressionHIV Research and TreatmentImmune Cell Function and InteractionReproductive System and Pregnancy