One-Pot Stereoselective Synthesis of 2,3-Diglycosylindoles and Tryptophan-C-glycosides via Palladium-Catalyzed C–H Glycosylation of Indole and Tryptophan
Yanan Ding, Ning Li, Yan‐Chong Huang, Wei‐Yu Shi, Nian Zheng, Cui‐Tian Wang, Yang An, Xue‐Yuan Liu, Yong‐Min Liang
Abstract
We described a novel palladium-catalyzed C-H glycosylation of indole or tryptophan for a one-pot stereoselective synthesis of 2,3-diglycosylindoles and tryptophan-C-glycosides. In this strategy, the use of air and base-free and ligand-free conditions provided a highly efficient route to construct C-glycosides. The method can be applied to a wide range of cost-effective and convenient glycosyl chloride donors. Mechanistic studies indicated that the indole 2,3-diglycosylation sequence was C3 and then C2.
Topics & Concepts
ChemistryIndole testStereoselectivityGlycosylationPalladiumTryptophanCatalysisCombinatorial chemistryGlycosylStereochemistryGlycosideOrganic chemistryAmino acidBiochemistryCatalytic C–H Functionalization MethodsCarbohydrate Chemistry and SynthesisSynthesis and Catalytic Reactions