Association between Microbiota and Nasal Mucosal Diseases in terms of Immunity
Junhu Tai, Mun Soo Han, Jiwon Kwak, Tae Hoon Kim
Abstract
The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.
Topics & Concepts
Mucosal immunityImmunologySinusitisImmune systemMicrobiomePathogenesisInflammationHeredityImmunityBiologyBioinformaticsMedicineGeneticsSinusitis and nasal conditionsAsthma and respiratory diseasesOral microbiology and periodontitis research