Porous Se@Sio <sub>2</sub> Nanoparticles Improve Oxidative Injury to Promote Muscle Regeneration Via Modulating Mitochondria
Yuxia Yang, Mingsheng Liu, Xijian Liu, Yucheng Zhang, Yang‐Yang Hu, Rang-Shan Gao, Erkai Pang, Lei Hou, Jingcheng Wang, Wenyong Fei
Abstract
Background: Acute skeletal muscle injuries are common among physical or sports traumas. The excessive oxidative stress at the site of injury impairs muscle regeneration. The authors have recently developed porous Se@SiO2 nanoparticles (NPs) with antioxidant properties. Methods: The protective effects were evaluated by cell proliferation, myogenic differentiation and mitochondrial activity. Then, the therapeutic effect was investigated in a cardiotoxin-induced muscle injury rat model. Results: Porous Se@SiO2 NPs significantly protected the morphological and functional stability of mitochondria, thus protecting satellite cells from H2O2-induced damage to cell proliferation and myogenic differentiation. In the rat model, intervention with porous Se@SiO2 NPs promoted muscle regeneration. Conclusion: This study reveals the application potential of porous Se@SiO2 NPs in skeletal muscle diseases related to mitochondrial dysfunction.