Overexpression of ABCB1 and ABCG2 contributes to reduced efficacy of the PI3K/mTOR inhibitor samotolisib (LY3023414) in cancer cell lines
Chung‐Pu Wu, Cheng‐Yu Hung, Sabrina Lusvarghi, Yang-Hui Huang, Pin-Jung Tseng, Tai‐Ho Hung, Jau‐Song Yu, Suresh V. Ambudkar
Topics & Concepts
Abcg2PI3K/AKT/mTOR pathwayEffluxCancer cellIn silicoATP-binding cassette transporterTransporterPharmacologyMultiple drug resistanceDrug resistanceBiologyCancer researchCancerChemistryCell biologyBiochemistrySignal transductionGeneMicrobiologyGeneticsDrug Transport and Resistance MechanismsHIV/AIDS drug development and treatmentPharmacological Effects and Toxicity Studies