α-Alkylation of Nitriles with Primary Alcohols by a Well-Defined Molecular Cobalt Catalyst
Keshav Raj Paudel, Shi Xu, Keying Ding
Abstract
The α-alkylation of nitriles with primary alcohols to selectively synthesize nitriles by a well-defined molecular homogeneous cobalt catalyst is presented. Thirty-two examples with up to 95% yield are reported. Remarkably, this transformation is environmentally friendly and atom economical with water as the only byproduct.
Topics & Concepts
AlkylationCatalysisPrimary (astronomy)CobaltHomogeneousEnvironmentally friendlyYield (engineering)ChemistryOrganic chemistryHomogeneous catalysisNitrileCombinatorial chemistryMaterials scienceMathematicsMetallurgyEcologyCombinatoricsBiologyAstronomyPhysicsAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisCarbon dioxide utilization in catalysis