Association of Relative Brain Hyperperfusion Independent of Dopamine Depletion With Motor Dysfunction in Patients With Parkinson Disease
Han Soo Yoo, Young‐gun Lee, Young H. Sohn, Mijin Yun, Jungho Cha, Phil Hyu Lee
Abstract
BACKGROUND AND OBJECTIVES: F-FP-CIT) PET, we investigated the role of brain perfusion in motor symptoms and disease progression, independent of striatal dopamine depletion. METHODS: -PP), the main region of dopamine deficit. Subsequently, we investigated the association of the SR with baseline and longitudinal motor symptoms and brain atrophy. RESULTS: = 0.017) and a decrease in brain volume. DISCUSSION: These results suggest that aberrant relative brain hyperperfusion, independent of striatal dopamine depletion, was associated with baseline and longitudinal motor deficits and progression of neurodegeneration in PD.
Topics & Concepts
DopamineParkinson's diseaseMedicineMotor symptomsNeuroscienceDiseaseInternal medicinePsychologyParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsTranscranial Magnetic Stimulation Studies