Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma
Seunghoon Kim, Hyun Jung Kee, Dahee Kim, Jinho Jang, Hyoung-oh Jeong, Nam Suk Sim, Mischa Selig, Jana Ihlow, Livius Penter, Taejoo Hwang, David Whee-Young Choi, Kyoung Jun Lee, Jae Woong Lee, Young Min Park, Semin Lee, Yoon Woo Koh
Abstract
mast cells, conferring an adverse prognosis. Our study provides insights into understanding the interplay between intratumoral heterogeneity and the tumor microenvironment of advanced HPV-negative OSCC.
Topics & Concepts
Basal cellTranscriptomeCellBiologyCancer researchComputational biologyMedicinePathologyGeneticsGeneGene expressionSingle-cell and spatial transcriptomicsRNA modifications and cancerCancer Cells and Metastasis