Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors
Pāvels Dimitrijevs, Marina Makrecka‐Kuka, Agnieszka Bogucka, Marko Hyvönen, Teodors Panteļejevs, Pavel Arsenyan
Topics & Concepts
PKM2ChemistryPyruvate kinaseMechanism of actionCancer cellKinaseGlycolysisGene isoformBiochemistryOxidative phosphorylationCancerEnzymeIn vitroBiologyGeneGeneticsMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismATP Synthase and ATPases Research