Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease
Kristiana Xhima, Kelly Markham-Coultes, H. Nedev, Stefan Heinen, H. Uri Saragovi, Kullervo Hynynen, Isabelle Aubert
Abstract
, did not. D3, delivered intravenously and noninvasively to the basal forebrain using MRI-guided focused ultrasound (MRIgFUS)-mediated blood-brain barrier (BBB) permeability activated TrkA-related signaling cascades and enhanced cholinergic neurotransmission. Recent clinical trials support the safety and feasibility of MRIgFUS BBB modulation in AD patients. Neuroprotective agents targeting TrkA, combined with MRIgFUS BBB modulation, represent a promising strategy to counter neurodegeneration in AD.
Topics & Concepts
CholinergicAgonistDiseaseFunction (biology)NeuroscienceCholinergic systemMedicineTropomyosin receptor kinase ACell biologyBiologyReceptorInternal medicineNerve growth factorUltrasound and Hyperthermia ApplicationsVagus Nerve Stimulation ResearchStress Responses and Cortisol