Highly Enantioselective Three-Component Povarov Reaction for Direct Construction of Azaspirocycles
Nan-Fang Mo, Ying Zhang, Zheng‐Hui Guan
Abstract
An asymmetric organocatalyzed three-component Povarov reaction to construct azaspirocycles has been developed. A chiral phosphoric acid OCF-CPA bearing o-CF3-aryl on the H8–BINOL-framework is highly efficient in the reaction. The reaction was carried out under mind conditions for synthesis of a range of azaspirocycles in high yields and high to excellent enantioselectivities, thus expending the substrate scope of the traditional Povarov reaction.
Topics & Concepts
ChemistryEnantioselective synthesisPhosphoric acidComponent (thermodynamics)Scope (computer science)Substrate (aquarium)ArylReaction conditionsOrganocatalysisCombinatorial chemistryCatalysisOrganic chemistryComputer scienceThermodynamicsOceanographyProgramming languageAlkylPhysicsGeologyAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsOxidative Organic Chemistry Reactions