Brain–Bone Axis in Physiological and Pathological Conditions
Luca Massaccesi, Massimiliano Marco Corsi Romanelli, Emanuela Galliera
Abstract
The brain-bone axis has garnered increasing attention over the years, leading to numerous studies that have unraveled the intricate bidirectional communication between the central nervous system (CNS) and skeletal metabolism. This review explores this profound relationship, examining the complex mechanisms that regulate it, the key players involved, and the clinical implications of its dysfunction in various pathological situations affecting the CNS and skeletal system. Ultimately, it emphasizes the potential of ongoing research to develop diagnostic tools, therapeutic interventions, and preventive strategies aimed at enhancing skeletal and neurological health.
Topics & Concepts
PathologicalNeuroscienceCentral nervous systemMedicineBioinformaticsNervous systemPathologyBiologyKey (lock)Skeletal muscleMechanism (biology)Bone health and osteoporosis researchBone Metabolism and DiseasesBone health and treatments