Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization
Hereward Wimborne, Jiangting Hu, Kenji Takemoto, Nga Nguyen, Hartmut Jaeschke, John J. Lemasters, Zhi Zhong
Topics & Concepts
AcetaminophenChemistryALDH2Lipid peroxidationLiver injuryMitochondrionAldehyde dehydrogenaseMitochondrial permeability transition poreOxidative stressBiochemistryPharmacologyEndocrinologyInternal medicineProgrammed cell deathBiologyApoptosisMedicineEnzymeDrug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationLiver Disease Diagnosis and Treatment