Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy
Hao-Ling Zhang, Doblin Sandai, Zhong-Wen Zhang, Zhijing Song, Dinesh Babu, Yasser Tabana, Sabbar Saad Dahham, Mowaffaq Adam Ahmed Adam, Yong Wang, Wei Wang, Hao-Long Zhang, Rui Zhao, Khaled Barakat, Mohammad Syamsul Reza Harun, Siti Nurfatimah Mohd Shapudin, Bronwyn Lok
Abstract
ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology. This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer. This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis, deciphering the intricate mechanisms governing AICD, elucidating its intricate involvement in cancer signaling pathways, and scrutinizing validated key genes. Moreover, the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.