Conformational changes and CO2-induced channel gating in connexin26
Deborah H. Brotherton, Christos G. Savva, Timothy J. Ragan, Nicholas Dale, Alexander D. Cameron
Abstract
alone is sufficient to cause conformational changes in the protein. Analysis of the conformational states shows that movements at the N terminus are linked to both subunit rotation and flexing of the transmembrane helices.
Topics & Concepts
GatingBiophysicsProtein subunitTransmembrane proteinChemistryHelix (gastropod)Gap junctionTransmembrane domainCrystallographyIon channelProtein structureConformational changeMembraneRotation (mathematics)BiologyBiochemistryReceptorIntracellularMathematicsSnailEcologyGeometryGeneConnexins and lens biologyHeat shock proteins researchNicotinic Acetylcholine Receptors Study