Synthetic polypeptides inhibit nucleic acid-induced inflammation in autoimmune diseases by disrupting multivalent TLR9 binding to LL37-DNA bundles
Xingliang Liu, Shi Chen, Jing Huang, Yibo Du, Zhi Luo, Yue Zhang, Lixin Liu, Yongming Chen
Topics & Concepts
Nucleic acidDNATLR9InflammationChemistryCell biologyBiochemistryBiophysicsBiologyImmunologyGeneGene expressionDNA methylationImmune Response and InflammationImmunotherapy and Immune ResponsesAntimicrobial Peptides and Activities