Detection of Mobile Colistin Resistance Gene <i>mcr-10.1</i> in a Conjugative Plasmid from <i>Enterobacter roggenkampii</i> of Chicken Origin in China
Changwei Lei, Yu Zhang, Yuting Wang, Hongning Wang
Abstract
The emergence of mobile colistin resistance (mcr) genes has raised a global concern (1–3), as colistin is considered a last-resort antimicrobial for treating fatal infections caused by multidrug-resistant or carbapenem-resistant Enterobacteriaceae. Ten mcr genes (mcr-1 to mcr-10) and a lot of variants have been identified since the finding of mcr-1 in 2016 in China (4–6). These mcr-positive bacteria have been found in humans, animals, meat, and the environment in more than 60 countries across six continents (5, 7). Very recently, mcr-10 was described in a nonconjugative IncFIA(HI1) plasmid recovered from a clinical Enterobacter roggenkampii strain 090065 in China (6). It shows 79.69% nucleotide identity to mcr-9 and confers a 4-fold increase in colistin MIC (from 1 to 4 mg/liter). Here, we report a conjugative plasmid harboring mcr-10 in E. roggenkampii of chicken origin in China.